TGF-β, FGF-2, angiopoietin-2, VEGF-1 |
Rat myocardial infarction model |
Triggered angiogenic and migratory effects at the site of the infarct to promote myocardial healing and improve the cardiac function. |
[1] |
NGF, HGF, IL-10, IL1-RA |
NOD/SCID mouse model |
Contributed to the prevention of apoptosis, increasing cell proliferation in the damaged liver. |
[86] |
TGF-β1, VEGF |
Mouse burn injury model |
Assisted in burn wound healing. |
[2] |
IGF-1 |
Mouse acute kidney injury model |
Exerted beneficial effects on tubular cell repair in acute kidney injury. |
[87] |
Angiogenin, IL-8, MCP-1, and VEGF |
Mouse hind limb ischemia model |
Represented efficient biomarkers for predicting vascular regenerative efficacy of MSCs. |
[4] |
IGF-1, VEGF, EGF, and bFGF |
Rat middle cerebral artery occlusion ischemia model |
Induced functional improvement, reduced infarct volume, and showed neuroprotection in ischemic rats. |
[88] |
TGF-β |
Rat stroke model |
Suppressed immune propagation in the ischemic rat brain. |
[89] |
SDF-1, VEGF, HGF, and IL-6 |
Rat skin wound model |
Enhanced the activity of dermal fibroblasts and keratinocytes to promote re-epithelialization and angiogenesis and, consequently, promoted wound healing. |
[5] |