Table 1.

An expanding array of vesicular trafficking regulators in IS assembly and ciliogenesis.

Function	Immunological Synapse	Primary Cilium
GTPases	Rab3 [132]; Rab4 [33]; Rab5 [33]; Rab8 [132,133]; Rab11 [33,132]-FIP3 [134,135]; Rab27 [132]; Rab29 [136]; Rab35 [137]; Rab37 [132]; ARL3 [138]	Rab5 [139]; Rab6 [121,140]; Rab8 [123]; Rab10 [141]; Rab11 [124,142]-FIP3 [143]; Rab17 [125]; Rab23 [144]; Rab29 [136]; ARF4 [120]; ARL3 [131,145]; ARL6 [146]
GEFs and GAPs	EPI64C [137]; ARL13B [138]	RP2 [145,147]; Rabaptin5 [148]; ASAP-1 [121]; Rabin8 [123]; TBC1D7 [125]; EVI5like [125]; ARL13 [149,150]
Adaptors	WASH [151,152]; MAL [132,153]; clathrin [154]; β-arrestin1 [155]; EB-1 [48]; Unc119 [138]; ARPC3 [22]	TRAPPII [124]; AP-1 [156]; AP-2 [139]; MAL [157]; EB-1 [67,158]; Unc119 [131]
SNAREs and tethers	SNAP-23 [32]; Syntaxin-4 and -17 [32,159]; VAMP-2, -3 and -7 [32,132,133,160]	Exocyst subunits (Sec10, Exo70) [126,129], Syntaxin-10 [161]; VAMP-7 [162]
Others	IFT20; IFT52; IFT54; IFT57; IFT88 [21,33]; ERGIC-53 [22]	IFT proteins [163]; BLOC-1 [129]; BBSome complex [164]

Regulators involved in the formation of the IS and the primary cilium include GTPases, guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), adaptors, soluble NFS attachment protein receptor (SNARE) proteins and tethering molecules that are listed in the table. Some molecules have been identified as specific regulators of IS assembly or ciliogenesis since their function in the formation of the homologue structure has not been assessed yet (in black). Others are now known as shared participants in the assembly of the IS and the primary cilium (in red).