Table 3.

Intracellular bacteria that target Rab proteins.

	Targeted Rab Protein	Mechanism	References
Mycobacterium tuberculosis	Rab5	Secretes a nucleoside diphosphate kinase that acts as GAP for Rab5, preventing early endosome antigen 1 (EEA1) recruitment. This arrests phagosome maturation	[183,184]
	Rab7a	Secretes a nucleoside diphosphate kinase that acts as GAP for Rab7a, preventing Rab-interacting lysosomal protein (RILP) recruitment. This inhibits lysosomal enzyme transport and phagosomal degradation	[184]
Chlamydia trachomatis	Rab5	Secretes CT147, homologue of EEA1, that prevents endosomal fusion and bacterial degradation	[185]
Broad-host Salmonella enterica	Rab32	Delivers a Rab32 GAP and a Rab32-specific protease to neutralize the Rab32/ biogenesis of lysosome-related organelles complex-3 (BLOC-3) antimicrobial pathway	[186,187]
	Rab29	Delivers a Rab29-specific protease	[188]
	Rab38	Delivers a Rab38-specific protease	[187]
	Rab9	Delivers SifA, an effector that sequesters Rab9, inhibiting the delivery of mannose 6-phosphate receptors (MPRs) and lysosomal enzymes to the Salmonella-containing vacuole (SCV)	[189]
Legionella pneumophila	Rab5	Secretes a GEF for Rab5 and the effector VipD that prevents the binding of Rab5 to downstream effectors blocking endosomal trafficking and lysosomal degradation	[190,191]
	Rab21	Secretes a GEF for Rab21	[190]
	Rab22	Secretes a GEF for Rab22 and VipD that prevents the binding of Rab22 to downstream effectors blocking endosomal trafficking and lysosomal degradation	[190,191]
	Rab1	Secretes GEF for Rab1 to recruits Rab1 to SCV and effectors that regulate Rab1 cycle to create a replicative organelle	[192,193,194,195,196,197,198]