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. 2019 Sep 3;10:4050. doi: 10.1038/s41467-019-11916-0

Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

Henry R Kranzler 1,2,✉,#, Hang Zhou 3,4,#, Rachel L Kember 1,2,#, Rachel Vickers Smith 2,5, Amy C Justice 3,4,6, Scott Damrauer 1,2, Philip S Tsao 7,8, Derek Klarin 9, Aris Baras 10, Jeffrey Reid 10, John Overton 10, Daniel J Rader 1, Zhongshan Cheng 3,4, Janet P Tate 3,4, William C Becker 3,4, John Concato 3,4, Ke Xu 3,4, Renato Polimanti 3,4, Hongyu Zhao 3,6, Joel Gelernter 3,4
PMCID: PMC6722074  PMID: 31481659

Correction to: Nature Communications 10.1038/s41467-019-09480-8, published online 2 April 2019.

In the original version of this Article, several numbers were given incorrectly in Tables 1 and 2 in columns 5 (EAF), 6 (N) and 7 (Z-score). The mistakes arose when one population was removed from the analyses but the numbers were not updated in the tables. These have now been corrected in both the HTML and PDF versions of the Article. The incorrect versions of these tables appear below as Tables 1 and 2 and the correct versions as Tables 3 and 4, respectively.

Table 1.

Genome-wide significant associations for AUDIT-C in the trans-population meta-analysis

rsID Chr:posa A1/A2 Geneb EAF N Z-score P_EA P_AA P_LA P_EAA P_SAA Effect P_ meta
rs1260326 2:27730940 C/T GCKR c 0.652 270,226 8.22 1.74 × 10−16 0.110 0.067 0.987 0.739 +++++ 2.04 × 10−16
rs2683616 2:58035555 A/G VRK2 d 0.624 211,399 6.22 1.80 × 10−9 NA 0.060 0.487 NA +?+−? 4.95 × 10−10
rs12639940 4:39420981 A/G KLB c 0.613 194,761 5.93 3.45 × 10−9 NA NA 0.626 NA +??+? 3.06 × 10−9
rs1229984 4:100239319 C/T ADH1B c 0.970 272,358 24.56 4.83 × 10−102 1.31 × 10−19 4.40 × 10−16 9.05 × 10−3 NA ++++? 3.62 × 10−133
rs142783062 4:100270960 D/I ADH1C c 0.345 271,444 9.82 2.04 × 10−14 4.75 × 10−7 4.90 × 10−4 0.019 0.779 +++++ 9.50 × 10−23
rs13107325 4:103188709 C/T SLC39A8 c 0.937 270,248 11.45 1.43 × 10−25 1.07 × 10−4 2.23 × 10−3 NA NA +++?? 2.24 × 10−30
rs4423856 4:150984857 T/C DCLK2 d 0.796 212,444 5.66 3.60 × 10−8 NA 0.289 0.574 0.144 +?+++ 1.48 × 10−8
rs2961816 5:50443691 A/C ISL1 d 0.683 260,828 5.74 1.24 × 10−7 0.021 0.641 0.932 0.137 +++++ 9.75 × 10−9
rs4841132 8:9183596 A/G PPP1R3B d 0.101 276,763 5.46 2.75 × 10−6 6.59 × 10−3 0.226 NA 0.148 −−−?+ 3.62 × 10−8
rs62033408 16:53827962 A/G FTO c 0.678 270,067 9.08 2.20 × 10−15 4.78 × 10−5 0.229 0.177 0.027 +++++ 1.11 × 10−19
rs9902512 17:47094274 C/G IGF2BP1 c 0.664 207,229 -5.81 3.81 × 10−8 NA 0.055 0.782 NA −?−−? 6.24 × 10−9
rs142997686 17:79419159 D/I BAHCC1 c 0.384 211,314 5.84 1.77 × 10−9 NA 0.944 0.434 0.840 +?−+− 5.39 × 10−9
rs75723348 22:41420679 T/G RBX1 d 0.736 275,328 5.55 2.97 × 10−7 0.063 0.072 0.536 0.579 +++++ 1.11 × 10−8
Open in a new tab

The loci shown represent completely independent signals after conditioning analyses

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian American

aHuman Genome hg19 assembly

bGene nearest to the lead SNP

cProtein-coding gene contains the lead SNP

dProtein-coding gene nearest to the lead SNP

Table 2.

Genome-wide significant associations for AUD in the trans-population meta-analysis

rsID Chr:posa A1/A2 Geneb EAF N Z-score P_EA P_AA P_LA P_EAA P_SAA Effect P_ meta
rs1260326 2:27730940 C/T GCKR c 0.651 271,763 7.33 1.44 × 10−16 0.679 0.778 0.830 0.820 +++−+ 2.27 × 10−13
rs540606 2:45138507 A/G SIX3 d 0.409 213,336 -6.49 2.84 × 10−10 NA 0.175 0.411 NA −?−−? 8.58 × 10−11
rs5860563 4:100047157 D/I ADH4 c 0.722 277,270 -6.21 7.63 × 10−5 9.85 × 10−7 0.035 NA 0.412 −−−?+ 1.12 × 10−9
rs1229984 4:100239319 C/T ADH1B c 0.969 273,904 19.54 4.51 × 10−74 4.18 × 10−5 5.81 × 10−17 0.032 NA ++++? 4.68 × 10−85
rs1612735 4:100258007 T/C ADH1C c 0.656 271,471 -8.86 1.75 × 10−14 6.42 × 10−5 0.022 0.938 0.054 −−−++ 7.90 × 10−19
rs13107325 4:103188709 C/T SLC39A8 c 0.937 271,784 7.60 2.73 × 10−14 0.064 0.363 NA NA +++?? 2.97 × 10−14
rs7906104 10:110497101 T/C 0.271 275,977 -5.98 3.15 × 10−7 8.72 × 10−3 0.357 0.195 0.106 −−−−− 3.17 × 10−9
rs61902812 11:113374420 A/C DRD2 d 0.306 276,977 -5.59 4.99 × 10−6 0.025 0.015 0.220 0.931 −−−−− 2.44 × 10−8
rs4936277e 11:113431960 A/G DRD2 d 0.599 274,128 7.44 2.85 × 10−11 0.073 4.36 × 10−4 0.200 0.357 +++++ 1.01 × 10−13
rs1421085 16:53800954 T/C FTO c 0.670 274,340 6.69 3.26 × 10−10 0.024 0.525 0.332 0.018 +++++ 2.17 × 10−11
Open in a new tab

The loci shown represent completely independent signals after conditioning analyses

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian Americans

aHuman Genome hg19 assembly

bGene nearest to the lead SNP

cProtein-coding gene contains the lead SNP

dProtein-coding gene nearest to the lead SNP

eDifferent signal than rs61902812

Table 3.

Genome-wide significant associations for AUDIT-C in the trans-population meta-analysis

rsID Chr:posa A1/A2 Geneb EAF N Z-score P_EA P_AA P_LA P_EAA P_SAA Effect P_ meta
rs1260326 2:27730940 C/T GCKR c 0.652 270,226 8.22 1.74 × 10−16 0.110 0.067 0.987 0.739 +++++ 2.04 × 10−16
rs2683616 2:58035555 A/G VRK2 d 0.624 211,399 6.22 1.80 × 10−9 NA 0.060 0.487 NA +?+-? 4.95 × 10−10
rs12639940 4:39420981 A/G KLB c 0.613 194,761 5.93 3.45 × 10−9 NA NA 0.626 NA +??+? 3.06 × 10−9
rs1229984 4:100239319 C/T ADH1B c 0.970 272,358 24.56 4.83 × 10−102 1.31 × 10−19 4.40 × 10−16 9.05 × 10−3 NA ++++? 3.62 × 10−133
rs142783062 4:100270960 D/I ADH1C c 0.345 271,444 9.82 2.04 × 10−14 4.75 × 10−7 4.90 × 10−4 0.019 0.779 +++++ 9.50 × 10−23
rs13107325 4:103188709 C/T SLC39A8 c 0.937 270,248 11.45 1.43 × 10−25 1.07 × 10−4 2.23 × 10−3 NA NA +++?? 2.24 × 10−30
rs4423856 4:150984857 T/C DCLK2 d 0.796 212,444 5.66 3.60 × 10−8 NA 0.289 0.574 0.144 +?+++ 1.48 × 10−8
rs2961816 5:50443691 A/C ISL1 d 0.683 260,828 5.74 1.24 × 10−7 0.021 0.641 0.932 0.137 +++++ 9.75 × 10−9
rs4841132 8:9183596 A/G PPP1R3B d 0.101 271,192 −5.51 2.75 × 10−6 6.59 × 10−3 0.226 NA 0.148 ---?+ 3.62 × 10−8
rs62033408 16:53827962 A/G FTO c 0.678 270,067 9.08 2.20 × 10−15 4.78 × 10−5 0.229 0.177 0.027 +++++ 1.11 × 10−19
rs9902512 17:47094274 C/G IGF2BP1 c 0.664 207,229 −5.81 3.81 × 10−8 NA 0.055 0.782 NA -?--? 6.24 × 10−9
rs142997686 17:79419159 D/I BAHCC1 c 0.384 211,314 5.84 1.77 × 10−9 NA 0.944 0.434 0.840 +?-+- 5.39 × 10−9
rs75723348 22:41420679 T/G RBX1 d 0.736 269,785 5.71 2.97 × 10−7 0.063 0.072 0.536 0.579 +++++ 1.11 × 10−8
Open in a new tab

The loci shown represent completely independent signals after conditioning analyses.

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian American

aHuman Genome hg19 assemblyGenome Browser - hg19 assembly

bGene nearest to the lead SNP

cProtein-coding gene contains the lead SNP

dProtein-coding gene nearest to the lead SNP

Table 4.

Genome-wide significant associations for AUD in the trans-population meta-analysis

rsID Chr:posa A1/A2 Geneb EAF N Z-score P_EA P_AA P_LA P_EAA P_SAA Effect P_ meta
rs1260326 2:27730940 C/T GCKR c 0.651 271,763 7.33 1.44 × 10−16 0.679 0.778 0.830 0.820 +++-+ 2.27 × 10−13
rs540606 2:45138507 A/G SIX3 d 0.409 213,336 −6.49 2.84 × 10−10 NA 0.175 0.411 NA -?--? 8.58 × 10−11
rs5860563 4:100047157 D/I ADH4 c 0.723 271,487 −6.09 7.63 × 10−5 9.85 × 10−7 0.035 NA 0.412 ---?+ 1.12 × 10−9
rs1229984 4:100239319 C/T ADH1B c 0.969 273,904 19.54 4.51 × 10−74 4.18 × 10−5 5.81 × 10−17 0.032 NA ++++? 4.68 × 10−85
rs1612735 4:100258007 T/C ADH1C c 0.656 271,471 −8.86 1.75 × 10−14 6.42 × 10−5 0.022 0.938 0.054 ---++ 7.90 × 10−19
rs13107325 4:103188709 C/T SLC39A8 c 0.937 271,784 7.60 2.73 × 10−14 0.064 0.363 NA NA +++?? 2.97 × 10−14
rs7906104 10:110497101 T/C 0.272 270,278 −5.92 3.15 × 10−7 8.72 × 10−3 0.357 0.195 0.106 ----- 3.17 × 10−9
rs61902812 11:113374420 A/C DRD2 d 0.304 271,218 −5.58 4.99 × 10−6 0.025 0.015 0.220 0.931 ----- 2.44 × 10−8
rs4936277e 11:113431960 A/G DRD2 d 0.599 274,128 7.44 2.85 × 10−11 0.073 4.36 × 10−4 0.200 0.357 +++++ 1.01 × 10−13
rs1421085 16:53800954 T/C FTO c 0.670 274,340 6.69 3.26 × 10−10 0.024 0.525 0.332 0.018 +++++ 2.17 × 10−11
Open in a new tab

The loci shown represent completely independent signals after conditioning analyses.

A1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA

East Asian American, SAA South Asian Americans

aHuman Genome hg19 assembly

bGene nearest to the lead SNP

cProtein-coding gene contains the lead SNP

dProtein-coding gene nearest to the lead SNP

eDifferent signal than rs61902812

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