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. 2019 Aug 6;11(8):395. doi: 10.3390/pharmaceutics11080395

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Adsorption kinetics and (B) adsorption isotherm of oxaliplatin (Oxa) on BMNPs. The line represents the non-linear weighted least-squares (NWLS) fitting of the experimental data according to the Langmuir–Freundlich (LF) model. The vertical error bars are smaller than the symbol. ζ potential calculated for both BMNPs and Oxa-BMNPs at pH values of (C) 7.4 and (D) 5.0. (E) Zero-field cooling (ZFC) and field cooling (FC) measurements for BMNPs and Oxa-BMNPs. (F) Kinetics of Oxa release from loaded Oxa–BMNPs over time at physiological pH (pH 7.4) and at acidic pH (pH 5) at 25 °C, also under hyperthermia conditions.