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. 2019 Aug 6;11(8):395. doi: 10.3390/pharmaceutics11080395

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transmission electron microscopy analysis of the BMNP internalization in colon cancer cells. Representative images the T-84 colon tumor cells showing extracellular (A) and intracellular (B) magnetic NPs (arrows). Magnification of the image (C) in which an outline around the intracellular BMNPs is shown, suggesting that it is inside a vesicle. Multivesicular body (D). Intracellular NPs surrounded by a membrane (E). Deteriorated cell nucleus (F). The dark border that is observed could be a sign of clathrin-mediated endocytosis (G and H).