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. 2019 Aug 6;9(8):348. doi: 10.3390/biom9080348

Figure 3.

Figure 3

High glucose-derived microparticles (MPs; 10 µg/mL) induce phosphorylation of the downstream target of extracellular signal-regulated kinase (ERK) pathway—ERK1/2—in naïve renal proximal tubular cells. (A) Representative Western blot of P-ERK1/2; and (B,C) densitometry analyses of P-ERK1 and P-ERK2 levels normalized to β-actin. Values were expressed as mean ± SEM; n = 3; * p < 0.05 versus no MPs (control); # p < 0.05 versus control MPs; P-ERK1/2 and ERK1/2: Phosphorylated and total extracellular signal-regulated kinases 1/2; iHG: Intermittent high glucose; cHG: Continuous high glucose.