Addendum

In the article “Altered Neuronal Mitochondrial Coenzyme A Synthesis in Neurodegeneration with Brain Iron Accumulation Caused by Abnormal Processing, Stability, and Catalytic Activity of Mutant Pantothenate Kinase 2,” by Paul T. Kotzbauer, Adam C. Truax, John Q. Trojanowski, and Virginia M.-Y. Lee, which appeared on pages 689-698 of the January 19, 2005 issue, the data indicate that translation initiation from a CTG codon 330 nucleotides downstream of the ATG codon does not occur when using the cDNA that the authors and others have amplified from human brain. However, there is evidence to support the existence of transcripts in humans that do not contain the ATG codon and use this CTG start site (Johnson et al., 2004). Thus different translation initiation sites may be used because of the existence of alternate transcripts, and additional work is needed to understand the potential alternate transcription and translation initiation sites for human PanK2.