Table 1.
In-vitro cytotoxicity of J. communis L or Its Active Constituents in Experimental Models.
| Fraction/Active constituent | Experimental model | Cytotoxic effect | Reference |
|---|---|---|---|
| Aqueous berry extract | MCF-7/AZ mammary carcinoma cells | The anti-proliferative effect due to inhibition of cellular receptor tyrosine kinases, insulin-like growth factor receptors (IGF-1R) and C-erbB2/HER2/neu receptors | Van Slambrouck et al. (2007) |
| Berry extract | Human neuroblastoma SH-SY 5Y cells | Activated cellular relocalization of p53 and DNA fragmentation dependent cell death by induction of p53 associated apoptosis through the potentiation and synergism by several plant phenolics | Lantto et al. (2016) |
| Ethyl acetate fraction of J. communis leaves | Cell viability assay on HepG2 cells | Fraction in WST-1 proliferation assay didn't affect HepG2 cell viability after treatment for 24 h at a concentration between 0-10 μg/ml | Ved et al. (2017) |
| Extract of areal part of J. communis | In-vitro assay on Human prostate cancer cells (PC-3), Human colon cancer cells (HCT-116) and mammary cancer cells (MCF-7) using MTT | Highest activity with the safest margin observed for the total methanolic extract against human breast cancer cell line (MCF-7) | Ghaly et al. (2016) |
| Diterpenes isocupressic and aryltetralin lignan deoxypodophyllotoxin from J. communis | Malignant – MB231 breast cancer cells | Induced caspase dependent programmed cell death (apoptosis); aryltetralin lignan deoxypodophyllotoxin inhibited cell survival pathways mediated by the MAPK/ERK and NK-kß signaling pathways within hours of treatment | Benzina et al. (2015) |
| Imbricatolic acid isolated from methanolic extract of ripe berries | p53 null CaLu-6 cells | Induced up-regulation of cyclic dependent kinase inhibitors and their accumulation in G1 phase of the cell cycle and also degradation of cyclines A, D1 and E | |
| Methanolic and aqueous berry extract | Colorectal cancer cell line CaCO2 and HeLa cervical cancer cell line | Block the proliferation of cells in both cell lines with IC50 between 500-2500 μg/ml | Fernandez and Edwin (2016) |