Table 4. List of functional clusters with a co-occurrence meaning the biological pathways common between the THCNs .
| Annotation cluster 1 | ||||
| Enrichment score 5.91 | ||||
| Category | Term | P- value | Count | Genes |
| KEGG_PATHWAY | Renal cell carcinoma | 3.45E-09 | 6 | ARNT, JUN, VHL, HIF-1α, VEGFA, AKT1, |
| BIOCARTA | Hypoxia-Inducible Factor in the cardiovascular system | 3.62E-09 | 6 | ARNT, HSP90AA1, JUN, VHL, HIF-1α, VEGFA |
| KEGG_PATHWAY | HIF-1α signaling pathway | 2.80E-08 | 6 | ARNT, VHL, HIF-1α, VEGFA, EGFR, AKT1 |
| GOTERM_BP_DIRECT | Regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) | 3.46E-07 | 4 | ARNT, VHL, HIF-1α, VEGFA |
| GOTERM_BP_DIRECT | Positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) | 3.05E-05 | 3 | ARNT, HIF-1α, VEGFA |
| BIOCARTA | VEGF, Hypoxia, and Angiogenesis | 3.30E-04 | 4 | ARNT, VHL, HIF-1α, VEGFA |
| GOTERM_BP_DIRECT | Response to hypoxia (GO:0001666) | 0.004 | 3 | ARNT, HIF-1α, VEGFA |
| Annotation cluster 2 | ||||
| Enrichment score: 4.43 | ||||
| Category | Term | P -value | Count | Genes |
| GOTERM_BP_DIRECT | Positive regulation of endothelial cell proliferation (GO:0001938) | 3.24E-08 | 5 | ARNT, JUN, HIF-1α, VEGFA, AKT1 |
| GOTERM_BP_DIRECT | Outflow tract morphogenesis (GO:0003151) | 0.0003 | 3 | JUN, HIF-1α, VEGFA |
| GOTERM_BP_DIRECT | Angiogenesis (GO:0001525) | 0.006 | 3 | JUN, HIF-1α, VEGFA |
| Annotation cluster 3 | ||||
| Enrichment score: 3.16 | ||||
| Category | Term | P -value | Count | Genes |
| KEGG_PATHWAY | Pathways in cancer (hsa05200) | 1.02E-10 | 9 | TP53, ARNT, HSP90AA1, JUN, VHL, HIF-1α, VEGFA, EGFR, AKT1 |
| GOTERM_MF_DIRECT | Enzyme binding (GO:0019899) | 3.42E-07 | 6 | TP53, JUN, VHL, HIF-1α, EGFR, AKT1 |
| UP_KEYWORDS | Ubl conjugation | 3.68E-04 | 6 | TP53, HSP90AA1, JUN, HIF-1α, EGFR, AKT1 |
| GOTERM_CC_DIRECT | Nucleoplasm (GO:0005654) | 6.99E-04 | 7 | TP53, ARNT, HSP90AA1, JUN, VHL, HIF-1α, AKT1 |
| UP_KEYWORDS | Nucleus | 0.0016 | 8 | TP53, ARNT, JUN, VHL, HIF-1α, TSGA10, EGFR, AKT1 |
| GOTERM_CC_DIRECT | Nucleus (GO:0005634) | 0.004 | 8 | TP53, ARNT, HSP90AA1, JUN, VHL, HIF-1α, EGFR, AKT1 |
| UP_KEYWORDS | Acetylation | 0.009 | 6 | TP53, ARNT, HSP90AA1, JUN, HIF-1α, AKT1 |
| GOTERM_CC_DIRECT | Cytosol (GO:0005829) | 0.013 | 6 | TP53, HSP90AA1, JUN, VHL, HIF-1α, AKT1 |
| UP_KEYWORDS | Phosphoprotein | 0.025 | 8 | TP53, ARNT, HSP90AA1, JUN, HIF-1α, TSGA10, EGFR, AKT1 |
BP: biological process; MF: molecular function; CC: cellular component. GO: Gene ontology.