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. 2019 Aug 30;21(10):1015–1035. doi: 10.1016/j.neo.2019.07.011

Figure 10.

Figure 10

Low expression of MCM2, MCM4, MCM6, and MKI67 is associated with increased probability of relapse-free survival in grade I breast cancer using the online survival analysis tool Kaplan-Meier Plotter (Gyorffy et al., 2010).

The association between MCM2, MCM4, MCM6, and MKI67 expression and relapse-free survival of breast cancer patients, when they were stratified according to the histological grade, was studied using the online survival analysis tool Kaplan-Meier Plotter. MCM2, MCM4, MCM6, and MKI67 mRNA expression was stratified into high or low expression using the median mRNA expression level as the cutoff point. In grade I breast cancer, low expression of each of MCM2, MCM4, MCM6, and MKI67 was associated with increased probability of relapse-free survival (P = .0095, .055, .00088, and .0065, respectively). In grade II breast cancer, this association was still observed for MCM2, MCM6, and MKI67 (P = .0006, <.001, and <.001, respectively) but not for MCM4 (P = .46). In grade III breast cancer, none of the four markers' expression maintained this association.