Table 4:

Individual and joint association of preterm birth and histological maternal vascular malperfusion (MVM) with child’s risk of neurodevelopmental disabilities (NDDs), including ASD, ADHD, and other DD^*

	Total n	NDD n	Unadjusted	Adjusted**
No MVM	627	406	1.0 (Ref)
MVM	404	262	1.00 (0.77, 1.30)	1.00 (0.76, 1.31)
Combined association of preterm with MVM
Term, no MVM	317	180	1.0 (Ref)
Term, MVM	194	120	1.23 (0.86, 1.78)	1.23 (0.85, 1.80)
Preterm, no MVM	310	226	2.05 (1.47, 2.86)	1.95 (1.38, 2.74)
Preterm, MVM	210	142	1.59 (1.10, 2.29)	1.51 (1.04, 2.20)
Preterm, no MVM, no CA	203	140	1.69 (1.17, 2.45)	1.58 (1.08, 2.32)
Preterm, MVM, and CA	29	17	1.08 (0.50, 2.33)	0.90 (0.40, 2.01)
Combined association of spontaneous preterm with MVM
Term, no MVM	317	180	1.0 (Ref)
Term, MVM	194	120	1.23 (0.86, 1.78)	1.24 (0.85, 1.82)
Spontaneous preterm, no MVM	225	166	2.14 (1.48, 3.10)	2.01 (1.37, 2.94)
Spontaneous preterm, MVM	91	61	1.55 (0.95, 2.53)	1.50 (0.91, 2.50)
Combined association of medically indicated preterm with MVM
Term, no MVM	317	180	1.0 (Ref)
Term, MVM	194	120	1.23 (0.86, 1.78)	1.24 (0.85, 1.81)
Medically indicated preterm, no MVM	85	60	1.83 (1.09, 3.06)	1.79 (1.05, 3.05)
Medically indicated preterm, MVM	119	81	1.62 (1.04, 2.53)	1.53 (0.97, 2.42)

^*ASD – Autism Spectrum Disorder; ADHD – Attention-Deficit/Hyperactivity Disorder; DD – Developmental disabilities. CA - Chorioamnionitis

^**Adjusted for maternal smoking, age, education, parity, race and child’s sex

Test of interactions were performed for all the above analyses, but none reached statistical significance (p<0.05)