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. 2019 Aug 8;19:737–748. doi: 10.1016/j.isci.2019.08.011

Figure 3.

Figure 3

Rice Rat Tracheal Cultures have Decreased ENaC Expression and Increased TMEM16A Expression Compared with Mice

(A–K) mRNA expression of α ENaC (A), β ENaC (B), and γ ENaC (C) in mouse and rice rat airway cultures. mRNA expression of α ENaC (D), β ENaC (E), and γ ENaC (F) in rice rat airway cultures treated with dexamethasone (DEX) and aldosterone (ALDO). mRNA expression of NR3C1 (G), NR3C2 (H), TMEM16A (I), CFTR (J), and CHRM3 (K). ENaC, epithelial sodium channel; CFTR, cystic fibrosis transmembrane conductance regulator; NR3C1, glucocorticoid receptor; NR3C2, mineralocorticoid receptor; TMEM16, transmembrane member 16A; CHRM3, muscarinic acetylcholine receptor 3. For (A–C) and (G–K), n = 4 cultures from mice (2 female cultures and 2 male cultures representing 6 female and 6 male subjects); n = 4 cultures from the rice rat (2 female cultures and 2 male cultures representing 6 female and 6 male subjects). For (D–F), n = 3 cultures from the rice rat (2 female cultures and 1 male culture representing 6 female and 3 male subjects). *p < 0.05 compared with mouse. All data are shown as mean ± SEM.