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. 2019 Sep 6;16:25. doi: 10.1186/s12977-019-0487-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Functional domains and predicted structures of the HTLV-1 Tax-1 and HTLV-2B Tax-2 transactivator proteins. The predicted structures were generated using the I-TASSER computer algorithm (https://zhanglab.ccmb.med.umich.edu) and modeled using UCSF-Chimera. a Diagram of the HTLV-1 Tax protein and its functional domains. NLS nuclear localization signal, NES nuclear export sequence, ZF zinc finger motif, LZ leucine zipper region. The sites of the M22 (dimerization), G148 V (NF-κB transactivation), and M47 (activation domain) mutations are indicated. b The HTLV-2 Tax-2B protein and its conserved functional domains are shown. The unique C-terminal aa residues 331–356 are not present within the HTLV-1 Tax protein. NLD nuclear localization determinant