Table 7. Summary of plasma axitinib pharmacokinetic parameters following multiple oral doses of axitinib alone and in combination with multiple oral doses of crizotinib (dose‐expansion cohort 1).

^aGeometric mean (geometric percent coefficient of variance) for all except median (range) for T_max.

Abbreviations: AUC_tau, area under the concentration‐time curve from time zero to time tau (τ), the dosing interval, where tau = 12 hours (twice‐daily dosing); C_max, maximum observed concentration; C_min, minimum concentration observed during the dosing interval; CL/F, apparent clearance; n, number of patients contributing to the summary statistics; T_max, time for C_max.