Table 4. Merestinib noncompartmental pharmacokinetic parameters for cycle 1, day 1 by dose.

Note: Values reported as geometric mean (% coefficient of variation).

^aMedian (min–max).

Some subjects were omitted from calculations based on insufficient data:

^b n = 2.

^c n = 3.

^d n = 24.

^e n = 37.

^f n = 10.

^g n = 50.

^h n = 39.

Abbreviations: AUC_0–∞, area under the concentration‐time curve from time 0 to infinity after the first dose; AUC_0–24, area under the concentration‐time curve from 0 to 24 hours after the first dose; CL/F, apparent total body clearance of drug calculated after oral administration; C_max, maximum concentration observed after first dose; t_1/2, half‐life; t_max, time when C_max was observed; V_z/F, apparent volume of distribution during the terminal phase after oral administration.