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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Cytokine. 2019 Jul 22;123:154776. doi: 10.1016/j.cyto.2019.154776

Fig. 2. IL-22 inhibits HSV-2.

Fig. 2.

(A, B) End1/E6E7 cells were treated with or without IL-22 at the indicated concentrations for 24 h prior to HSV-2 infection. Intracellular and extracellular HSV-2 gD gene expression was measured at 48 h post HSV-2 infection. (C, D) For IL-22 receptor pretreatment, the anti-IL-22R1 antibody and anti-IL-10R2 antibody (10 μg/mL) were added to End1/E6E7 cell cultures for 1 h prior to IL-22 treatment. Intracellular and extracellular HSV-2 gD gene expression was measured at 48 h post HSV-2 infection. The results are the mean ± SD of triplicate cultures, representative of three independent experiments (*P < 0.05, **P < 0.01).