End1/E6E7 cells were treated with or without JAK inhibitor (JAK Inh), STAT1 inhibitor (Fludarabine) or STAT3 inhibitor (Stattic) for 1h and incubated with IL-22 for additional 24 h prior to HSV-2 infection. Intracellular (A, C, E) and extracellular (B, D, F) HSV-2 gD gene expression was measured at 48 h post HSV-2 infection. Data are shown as mean ± SD for three independent experiments (*P < 0.05, **P < 0.01, N. S., not significant).