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. 2007 May 1;9(2):303–319. doi: 10.1111/j.1582-4934.2005.tb00357.x

Neural stem cells in inflammatory CNS diseases: mechanisms and therapy

T Magnus 1,✉, M S Rao 1
PMCID: PMC6740148  PMID: 15963251

Abstract

Autoimmune inflammatory diseases of the central nervous system (CNS) are highly complex in their interaction of different cell populations. The main therapy focus in the last years has been the inhibition of the immune system. Recent progress has shown that endogenous as well as transplanted neural stem cells might positively influence the outcome of such diseases. In this review, we discuss the current concept of the underlying pathogenesis with a specific focus on local CNS cells and potential treatment options.

Keywords: matrix metalloproteinases (MMPs), angiogenesis, tumor angiogenesis, MMP inhibitors, extracellular matrix remodeling, tissue inhibitors of metalloproteinases (TIMPs), thrombospondins

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