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. 2007 May 1;6(4):453–464. doi: 10.1111/j.1582-4934.2002.tb00449.x

Sarcolemmal and mitochondrial KATP channels and myocardial ischemic preconditioning

J N Peart 1, G J Gross 1,✉
PMCID: PMC6741323  PMID: 12611635

Abstract

Ischemic preconditioning (IPC) is the phenomenon whereby brief periods of ischemia have been shown to protect the myocardium against a sustained ischemic insult. The result of IPC may be manifest as a marked reduction in infarct size, myocardial stunning, or incidence of arrhythmias. While many substances and pathways have been proposed to play a role in the signal transduction mediating the cardioprotective effect of IPC, overwhelming evidence indicates an intimate involvement of the ATP‐sensitive potassium channel (KATP channel) in this process. Initial hypotheses suggested that the surface or sarcolemmal KATP (sarcKATP) channel mediated the cardioprotective effects of IPC. However, much research has subsequently supported a major role for the mitochondrial KATP channel (mitoKATP) as the one involved in IPC‐mediated cardioprotection. This review presents evidence to support a role for the sarcKATP or the mitoKATP channel as either triggers and/or downstream mediators in the phenomenon of IPC.

Keywords: ischemic preconditioning, ATP‐sensitive K+ channel, mitochondria, sarcolemma

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