Skip to main content
Journal of Cellular and Molecular Medicine logoLink to Journal of Cellular and Molecular Medicine
. 2007 May 1;7(3):197–203. doi: 10.1111/j.1582-4934.2003.tb00220.x

Surface wound healing: a new, general function of eukaryotic cells

J Meldolesi 1,
PMCID: PMC6741416  PMID: 14594544

Abstract

The ability to repair surface wounds is a property, necessary for long‐term survival, expressed to various extents by all eukaryotic cell types except erythrocytes. The process is based on the rapid Ca2+‐induced exocytosis of various types of specific organelles, such as lysosomes and enlargeosomes, that decreases surface tension and makes possible the spontaneous fusion of lipid monolayers at the lesion edges. The recognized importance of the process in physiology and in several cases of pathology is discussed.

Keywords: membrane repair, membrane surface tension, exocytosis, lysosomes, enlargeosomes, calcium

References

  • 1. Heilbrunn L.V., The surface precipitation reaction of living cells, Proc. Am. Philos. Soc., 419: 295–301, 1930. [Google Scholar]
  • 2. McNeil P.L., Steinhardt R.A., Loss, restoration, and maintenance of plasma membrane integrity, J. Cell Biol., 137: 1–4, 1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. McNeil P.L., Terasaki M., Coping with the inevitable: how cells repair a torn surface membrane, Nat. Cell Biol., 3: E124–129, 2001. [DOI] [PubMed] [Google Scholar]
  • 4. Terasaki M., Miyake K., McNeil P.L., Large plasma membrane disruptions are rapidly resealed by Ca2+‐dependent vesicle‐vesicle fusion events, J. Cell Biol., 139: 63–74, 1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5. Andrews N.W., Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship, J. Cell Biol., 158: 389–394, 2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6. Jaiswal J.K., Andrews N.W., Simon S.M., Membrane proximal lysosomes are the major vesicles responsible for calcium‐dependent exocytosis in nonsecretory cells, J. Cell Biol., 159: 625–635, 2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. Bansal D., Miyake K., Vogel S.S., Groh S., Chen C.C., Williamson R., McNeil P.L., Campbell K.P., Defective membrane repair in dysferlin‐deficient muscular dystrophy, Nature, 423: 168–172, 2003. [DOI] [PubMed] [Google Scholar]
  • 8. Togo T., Krasieva T.B., Steinhardt R.A., A decrease in membrane tension precedes successful cell‐membrane repair, Mol. Biol. Cell, 11: 4339–4346, 2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. Eddleman C.S., Ballinger M.L., Smyers M.E., Godell C.M., Fishman H.M., Bittner G.D., Repair of plasmalemmal lesions by vesicles, Proc. Natl. Acad. Sci. USA, 94: 4745–4750, 1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10. Togo T., Alderton J.M., Bi G.Q., Steinhardt R.A., The mechanism of facilitated cell membrane resealing, J. Cell Sci., 112: 719–731, 1999. [DOI] [PubMed] [Google Scholar]
  • 11. McNeil P.L., Miyake K., Vogel S.S., The endomembrane requirement for cell surface repair, Proc. Natl. Acad. Sci. USA, 100: 4592–4597, 2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12. Miyake K., McNeil P.L., Vesicle accumulation and exocytosis at sites of plasma membrane disruption, J. Cell Biol., 131: 1737–1745, 1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13. Terasaki M., Miyake K., McNeil P.L., Large plasma membrane disruptions are rapidly resealed by Ca2+‐dependent vesicle‐vesicle fusion events, J. Cell Biol., 139: 63–74, 1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14. Ninomiya Y., Kishimoto T., Miyashita Y., Kasai H., Ca2+‐ dependent exocytotic pathways in Chinese hamster ovary fibroblasts revealed by a caged ‐ Ca2+ compound, J. Biol. Chem., 271: 17751–17754, 1996. [DOI] [PubMed] [Google Scholar]
  • 15. Kasai H., Kishimoto T., Liu T.T., Miyashita Y., Podini P., Grohovaz F., Meldolesi J., Multiple and diverse forms of regulated exocytosis in wild‐type and defective PC12 cells, Proc. Natl. Acad. Sci. U S A, 96: 945–949, 1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16. Togo T., Alderton J.M., Steinhardt R.A., Long‐term potentiation of exocytosis and cell membrane repair in fibroblasts, Mol. Biol. Cell., 14: 93–106, 2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Borgonovo B., Cocucci E., Racchetti G., Podini P., Bachi A., Meldolesi J., Regulated exocytosis: a novel, widely expressed system, Nat. Cell Biol., 4: 955–962, 2002. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Cellular and Molecular Medicine are provided here courtesy of Blackwell Publishing

RESOURCES