Abstract
We investigated the effect of H. pylori infection on cell proliferation of gastric mucosa using immunostaining for H. pylori or Ki67. H. pylori cells attached to surface mucous cells covering luminal surface and the upper part of gastric foveolae, and up‐regulated the proliferative activity of gastric epithelial cells without adhering to the proliferating epithelial cells.
Keywords: Helicobacter pylori, gastric surface epithelial cell, gastric proliferating zone, gastric mucin, immunohistochemistry
References
- 1. Shimizu T, Akamatsu T, Sugiyama A, Ota H, Katsuyama T. Helicobacter pylori and the surface mucous gel layer of the human stomach. Helicobacter 1996; 61: 207–18. [DOI] [PubMed] [Google Scholar]
- 2. Yabuki N, Sasano H, Tobita M, Imatani A, Hoshi T, Kato K, Ohara S, Asaki S, Toyota T, Nagura H. Analysis of cell damage and proliferation in Helicobacter pylori‐infected human gastric mucosa from patients with gastric adenocarcinoma. Am J Pathol. 1997; 151: 821–9. [PMC free article] [PubMed] [Google Scholar]