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Pharmacophore mapping of five hits on model. Pharmacophore features are color-coded: Red, one hydrogen-bond acceptor feature (F1: Acc); yellow, aromatic features (F2 and F3: Aro); blue, one hydrophobic feature (F4: Hyd). The hits are shown in stick form; protein backbone and active site residues (green) are shown in line form; red balls mean water molecules; a gray pocket represents the shape of the binding site in tubulin.
