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In vitro tumor cell-binding properties and cellular internalization of 99mTc-HER2 and 99mTc-MUC1 to respective receptor-positive breast cancer cell lines.
| Cell Line | Kd (nM) | % Internalization | |
|---|---|---|---|
| 99mTc-HER2 | SKBR3 | 49.97 ± 14.15 | 19.90 ± 5.35 |
| MCF7 | 157.92 ± 24.60 | 12.16 ± 3.20 | |
| T47D | 169.44 ± 22.29 | 11.85 ± 2.83 | |
| 99mTc-MUC1 | MCF7 | 10.30 ± 1.55 | 18.92 ± 2.16 |
| T47D | 3.48 ± 0.84 | 21.11 ± 2.95 |
