Figure 1.

(A) Putative binding structures of double-stranded DNA with pyrrole-imidazole (PI) polyamide targeting human transforming growth factor-β1. Target DNA binding site is indicated by blue and pink colors. PI polyamides are indicated by yallow and red colors. (B) Principle of transcriptional suppression of genes. PI polyamides bind to the target promoter region of targeting genes by hydrogen binding to prevent binding of the transcription factors to transcriptionally suppress the gene expression.