Figure 3.

The effects of pyrrole-imidazole polyamide targeting human TGF-β1 (Polyamide) on fibrosis in marmosets with cyclosporin A (CsA)-induced nephropathy. Male marmosets were housed and fed with a 0.05% NaCl and 0.05% magnesium diet and subcutaneously injected with CsA (40 mg/kg/day) for eight weeks. Marmosets with CsA-nephropathy were intravenously injected with Polyamide (1 mg/kg/week for four weeks) from four weeks after the start of CsA injection. Sections (thickness: 4 µm) of kidney tissue samples were stained with hematoxylin-eosin (HE) and Masson trichrome (Masson).