Table 3. Uni- and multivariate proportional hazard regression analysis for competing events of 90-day organ failure development.

In univariate regression high sCD163, sCD206 and osteopontin levels are significantly associated with organ failure development at 90 days besides other clinical factors and laboratory parameters. High OPN level, age and AST/ALT ratio are independent predictors.

	Univariate Fine-Gray proportional hazard regression			Multivariate Fine-Gray proportional hazard regression
	Hazard ratio	95%CI	p value	Hazard ratio	95%CI	p value
Age	1.055	0.9949–1.119	0.073	1.142	1.048–1.243	0.0024
Gender	0.7412	0.2262–2.428	0.62
Cirrhosis*	2.153	0.2506–18.5	0.48
Ascites*	8.396	2.216–31.81	0.0017	2.335	0.5189–10.500	0.27
Encephalopathy*	1.649	0.4481–6.069	0.45
MELD score	1.246	1.101–1.411	0.00051	1.028	0.7652–1.380	0.86
Maddrey Df	1.048	1.025–1.073	>0.0001	1.012	0.9807–1.044	0.46
Albumin	0.2581	0.1306–0.51	0.0001	1.018	0.1493–6.934	0.99
Alk. Phos.	1.004	0.9991–1.008	0.12
ALT	1.008	0.9923–1.024	0.32
AST	1.009	1.004–1.014	0.00017	1.00	0.9935–1.007	0.91
AST/ALT	2.594	1.518–4.433	0.00049	5.699	1.599–20.310	0.0073
WBC	1.011	0.8994–1.136	0.86
sCD163	14.62	1.92–111	0.0095	1.136	0.1069–12.070	0.92
sCD206	17.31	2.24–133.8	0.0063	2.749	0.3002–25.180	0.37
OPN	14.36	2.02–102.1	0.0078	9.789	2.729–35.120	0.00047
LBP	2.36	0.7833–7.11	0.13

HR: hazard ratio; CI: Confidence interval; DF: discriminant factor; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AST/ALT: AST-ALT ratio; Alk. Phos.: alkaline phosphatase; WBC: white blood cell; OPN: osteopontin, LBP: lipopolysaccharide binding protein

^*present/absent