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. 2019 Jan 30;38(21):4002–4014. doi: 10.1038/s41388-019-0680-2

Fig. 9.

Fig. 9

Trichrome staining reveals desmoplasia in cMASC admixed tumors in vivo and in human samples. a Formalin fixed paraffin embedded whole sections of mouse tumors from control CM04-PDC only tumors and mixed tumors of CM04:CM08 co-implantation. Panel I: CM04-PDC only; Panel II: 1:1 CM08-cMASC:CM04-PDC; Panel III: 3:1 CM08-cMASC:CM04-PDC; Panel IV: 1:3 CM08-cMASC:CM04-PDC. Staining revealed a fibrotic response (desmoplasia), indicated by deposition of abundant collagen matrices (blue staining) only in mixed tumors. b Trichrome staining of patient tumors for CM01, 02, 03, and 08 also showed an extensive desmoplastic response (blue staining)