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. 2019 Feb 11;38(23):4590–4604. doi: 10.1038/s41388-019-0743-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — PKNOX2 suppressed gastric tumor growth in vivo. a Ectopic expression of PKNOX2 suppressed the growth of MKN45 xeongrafts in vivo. b Representative image of MKN45 xenografts in nude mice (upper). PKNOX2 overexpression reduced both tumor volume (P < 0.001) and weight (P < 0.05) (lower). c Overexpression of PKNOX2 in MKN45 xenografts was confirmed by RT-PCR. d PKNOX2 inhibited cell proliferation in vivo, as evidenced by Ki-67 staining(P < 0.01). e Ectopic expression of PKNOX2 suppressed the growth of AGS xeongrafts in NOD-SCID mice. f Representative image of AGS xenografts (upper). PKNOX2 overexpression reduced both tumor volume and weight (lower)(both P < 0.001). g Overexpression of PKNOX2 in AGS xenografts was confirmed by RT-PCR. (*P < 0.05; **P < 0.01; ***P < 0.0001)