Figure 2. EC-Exo pass the BBB:
Intravenously injected EC-Exo (A) pass the BBB and home to the ischemic brain and co-localize with CD9 and CD63, and (B-D) are internalized by endogenous brain cells such as neurons, ECs, macrophages, microglia but were not detected in the cell body of astrocytes and oligodendrocytes.