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. 2019 Jul 30;160(10):2453–2463. doi: 10.1210/en.2019-00195

Figure 3.

Figure 3.

The stimulatory action of NKA is independent of NKB in the presence of physiological circulating levels of E2. (A) LH release before (basal), 25 and 60 min after the icv injection of NK2R-Ag, senktide, or the coadministration of both (600 pmol/5 μL icv) in WT OVX+E2 females (n ≥ 5 per group). *P < 0.05 vs corresponding basal levels (two-way ANOVA followed by Tukey post hoc test). For SB222200-treated mice, LH levels before (basal) SB222200 (7 nmol/5 μL icv) administration and at 25 and 60 min after injection of NK2R-Ag (600 pmol/5 μL icv), senktide (600 pmol/5 μL icv), or vehicle (0.9% NaCl/5 μL icv) in WT OVX+E2 females (n ≥ 4 per group). *P < 0.05 vs corresponding basal levels. (B) LH before (basal) and at 25 and 60 min after injection of NK2R-Ag (600 pmol/5 μL icv) in OVX+E2 WT and Tac2KO females (n ≥ 5 per group). *P < 0.05 vs corresponding basal levels (two-way ANOVA followed by Tukey post hoc test).