Abstract
Effects of benidipine hydrochloride or triple therapy (hydralazine, reserpine, and hydrochlorothiazide) on renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity were evaluated in stroke‐prone spontaneously hypertensive rats (SHR‐SP) as an animal model for human essential hypertension with cerebral stroke. This study showed a significant decrease of renal intrinsic glutathione peroxidase (GSH‐Px) activity in untreated SHR‐SP. Renal GSH‐Px activity in untreated SHR‐SP was significantly lower than that in Wister Kyoto rats (WKY) as a normotensive reference strain. GSH‐Px activity in SHR‐SP was significantly improved after benidipine hydrochloride therapy. Levels of urinary albumin excretion or creatinine clearance (Ccr) in SHR‐SP were also improved after the therapy. Glomerular sclerosis index was slightly improved in SHR‐SP treated with benidipine hydrochloride according to light microscopic analysis. It appears that hypertension may influence the renal intrinsic GSH‐Px activity, albuminuria, and Ccr in SHR‐SP. Thus it is indicated that control of blood pressure may improve the GSH‐Px activity in SHR‐SP. J. Clin. Lab. Anal. 11:158–162, 1997. © 1997 Wiley‐Liss, Inc.
Keywords: renal AOE activity, benidipine hydrochloride, SHR‐SP
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