Table 2.

Correlation with clinical phenotypes collected from the UK Biobank participants

Locus	Category	UK Biobank phenotype	Beta	Direction a	Uncorrected P
rs199512	Mental health	Neuroticism score	−0.086	+	3.70 × 10−16
	Mental health	Sensitivity / hurt feelings	−0.013	+	5.10 × 10−18
	Mental health	Mood swings	−0.011	+	1.20 × 10−13
	Mental health	Frequency of tenseness / restlessness in last 2 weeks	−0.011	+	4.80 × 10−10
	Illnesses	Pain type(s) experienced in last month: headache	−0.0089	+	4.60 × 10−14
	Mental health	Fed-up feelings	−0.0087	+	2.90 × 10−9
	Mental health	Irritability	−0.0081	+	2.00 × 10−9
	Mental health	Miserableness	−0.0077	+	1.20 × 10−7
	Mental health	Worrier / anxious feelings	−0.007	+	1.60 × 10−6
	Mental health	Nervous feelings	−0.0068	+	8.80 × 10−8
	Illnesses	Mouth/teeth dental problems: mouth ulcers	−0.0054	+	1.40 × 10−9
	Family illnesses	Illnesses of mother: Parkinson’s disease	0.0018	−	1.90 × 10−6
	Non-cancer illness	Non-cancer illness code, self-reported: helicobacter pylori	0.0007	−	3.70 × 10−6
rs3094128	Mental health	Seen doctor (GP) for nerves, anxiety, tension or depression	−0.0094	+	1.00 × 10−11
	Non-cancer illness	Non-cancer illness code, self-reported: asthma	0.0077	−	4.70 × 10−16
	Illnesses	Diagnosed by doctor: Asthma	0.0076	−	9.50 × 10−16
	Illnesses	Hearing difficulty/problems with background noise	−0.0072	+	5.50 × 10−7
	Illnesses	Mouth/teeth dental problems: dentures	0.0066	−	2.10 × 10−9
	Non-cancer illness	Non-cancer illness code, self-reported: malabsorption/coeliac disease	0.0055	−	9.8 × 10−182
	Mental health	Tense / ‘highly strung’	−0.0052	+	4.60 × 10−6
	Mental health	Seen a psychiatrist for nerves, anxiety, tension or depression	−0.005	+	6.90 × 10−8
	Illnesses	Eye problems/disorders: diabetes-related eye disease	0.0034	−	1.80 × 10−6
	Non-cancer illness	Non-cancer illness code, self-reported: hypothyroidism/myxoedema	0.0033	−	9.60 × 10−8
	Non-cancer illness	Non-cancer illness code, self-reported: hyperthyroidism/thyrotoxicosis	0.0029	−	3.40 × 10−29
	Illnesses	Diabetes diagnosed by doctor	0.0029	−	5.10 × 10−6
	Illnesses	Doctor diagnosed sarcoidosis	0.0027	−	6.50 × 10−13
	ICD-10 codes	Diagnoses: main ICD10: R31 Unspecified haematuria	−0.0027	+	2.50 × 10−10
	ICD-10 codes	Diagnoses: main ICD10: K90 Intestinal malabsorption	0.0022	−	8.80 × 10−68
	Non-cancer illness	Non-cancer illness code, self-reported: psoriasis	−0.0017	+	2.90 × 10−8
	Non-cancer illness	Non-cancer illness code, self-reported: enlarged prostate	−0.0016	+	1.20 × 10−6
	ICD-10 codes	Diagnoses: main ICD10: N40 Hyperplasia of prostate	−0.0013	+	3.30 × 10−6
	Non-cancer illness	Non-cancer illness code, self-reported: ankylosing spondylitis	−0.0008	+	2.70 × 10−7
	Non-cancer illness	Non-cancer illness code, self-reported: sarcoidosis	0.0008	−	4.90 × 10−10
	Non-cancer illness	Non-cancer illness code, self-reported: systemic lupus erythematosis	0.0005	−	2.90 × 10−7
	ICD-10 codes	Diagnoses: main ICD10: E10 Insulin-dependent diabetes mellitus	0.00048	−	4.40 × 10−6
	Non-cancer illness	Non-cancer illness code, self-reported: type 1 diabetes	0.00039	−	5.80 × 10−6

Two loci associated with left-handedness (rs199512 and rs3094128) were also significantly associated with numerous mental health variables and with familial history of Parkinson’s disease in the genotyped UK Biobank participants. Only results surviving correction for multiple comparisons across loci (n = 4) and across clinical phenotypes (n = 1345, Supplementary material) are presented, and these are ranked by effect size. Clinical phenotypes directly related to neurological or mental health symptoms are highlighted in bold.

^aDirection refers of the correlation between the phenotype in question and the allele that predisposes to non-right-handedness for rs199512 and rs3094128. A positive value indicates that the allele predisposing to non-right-handedness is positively correlated with the phenotype.