Table 3.
The regulation of expression and the function of the nine DE mRNAs that exhibited the same trend of expression in boar and giant panda sperm.
| mRNA | Boar | Giant Panda | Functions |
|---|---|---|---|
|
GLT8D2 (Glycosyltransferase 8 Domain Containing 2) |
up | up | Participates in nonalcoholic fatty liver disease (NAFLD) pathogenesis [37,38]. |
|
CLK2 (CDC Like Kinase 2) |
down | down | Acts as a hepatic gluconeogenesis and glucose output suppressor that inhibits transcriptional activity of PPARGC1A on gluconeogenic genes via its phosphorylation [39,40,41,42]. |
|
PHACTR3 (Phosphatase and Actin Regulator 3) |
up | up | Regulates cell morphogenesis, enhances cell spreading and motility through direct interaction with actin [43,44]. |
|
RHBDD3 (Rhomboid Domain Containing 3) |
up | up | Acts as a critical regulator of dendritic cell activation [45,46]. |
|
ATAT1 (Alpha Tubulin Acetyltransferase 1) |
up | up | Affects intracellular transport, cell motility, cilia formation, and neuronal signaling [47]. |
|
METTL1 (Methyltransferase Like 1) |
down | down | Mediates tRNA Methylome [48]. |
|
DPF1 (Double PHD Fingers 1) |
up | up | Promotes the formation of semen-derived virus infection enhancer and semenogelin fibrils [49]. |
|
SERTAD4 (SERTA Domain Containing 4) |
down | down | Interacts with I-mfa domain proteins and negatively regulates transcriptional activity of SERTA domain proteins [50]. |
|
S1PR5 (Sphingosine-1-Phosphate Receptor 5) |
up | up | Regulates trafficking of monocytes and influences natural killer (NK) cell distribution [51,52]. |