Table 2.
Anthropometric measures and metabolic profile of 200 adult females with obesity according to blunted GH peak or IGF-I SDS.
| Parameters | Blunted GH Peak 1 n = 123, 61.5% |
Normal GH Peak 2 n = 77, 35.8% |
p-Value | IGF-1 Deficiency 3 n = 142 (71.0%) |
IGF-1 Sufficiency 4 n = 58 (29.0%) |
p-Value |
|---|---|---|---|---|---|---|
| BMI (kg/m2) | 47.47 ± 6.05 | 41.54 ± 4.84 | <0.001 | 46.61 ± 6.06 | 41.70 ± 5.53 | <0.001 |
| Waist circumference (cm) | 132.11 ± 16.33 | 118.18 ± 14.60 | <0.001 | 129.98 ± 16.09 | 118.83 ± 16.88 | <0.001 |
| SBP (mmHg) | 130.83 ± 15.41 | 120.58 ± 12.87 | <0.001 | 129.19 ± 15.17 | 121.24 ± 14.21 | 0.001 |
| DBP (mmHg) | 83.33 ± 9.32 | 76.45 ± 11.77 | <0.001 | 82.16 ± 10.02 | 77.05 ± 11.94 | 0.002 |
| GH peak response (µg/L) | - | - | - | 2.14 ± 2.78 | 7.59 ± 4.88 | <0.001 |
| IGF-1 (µg/L) | 120.94 ± 44.41 | 201.45 ± 61.91 | <0.001 | - | - | - |
| IGF-1 (SDS) | −3.26 ± 1.12 | −1.11 ± 2.04 | <0.001 | - | - | - |
| Fasting Glucose (mg/dL) | 115.00 ± 40.41 | 89.73 ± 22.94 | <0.001 | 111.67 ± 39.12 | 89.66 ± 24.32 | <0.001 |
| Fasting Insulin (µU/mL) | 24.47 ± 11.59 | 12.73 ± 7.77 | <0.001 | 22.50 ± 11.52 | 13.71 ± 9.93 | <0.001 |
| Total cholesterol (mg/dL) | 195.06 ± 48.20 | 175.08 ± 45.00 | 0.004 | 192.02 ± 47.82 | 175.97 ± 46.49 | 0.031 |
| HDL cholesterol (mg/dL) | 48.09 ± 11.41 | 53.47 ± 12.10 | 0.002 | 48.59 ± 11.57 | 54.00 ± 12.07 | 0.004 |
| LDL cholesterol (mg/dL) | 114.55 ± 50.28 | 93.77 ± 47.00 | 0.004 | 111.39 ± 49.88 | 94.68 ± 48.55 | 0.031 |
| Fasting Triglycerides (mg/dL) | 159.94 ± 53.09 | 139.19 ± 50.89 | 0.007 | 158.30 ± 52.05 | 136.37 ± 52.87 | 0.008 |
| AST (U/L) | 31.17 ± 16.64 | 28.52 ± 16.08 | 0.268 | 30.25 ± 16.36 | 29.91 ± 16.77 | 0.897 |
| ALT (U/L) | 41.54 ± 32.53 | 41.96 ± 26.27 | 0.919 | 41.56 ± 31.25 | 42.03 ± 27.75 | 0.921 |
| γGT (U/L) | 42.26 ± 22.50 | 37.14 ± 19.31 | 0.089 | 42.34 ± 21.61 | 35.28 ± 20.27 | 0.030 |
| CRP (ng/mL) | 2.46 ± 1.02 | 2.12 ± 0.96 | 0.019 | 2.47 ± 1.00 | 1.98 ± 0.95 | 0.002 |
| HoMA-IR | 7.81 ± 7.07 | 3.20 ± 4.36 | <0.001 | 7.08 ± 6.83 | 3.49 ± 5.02 | <0.001 |
| VAI | 2.06 ± 1.01 | 1.55 ± 0.69 | <0.001 | 2.00 ± 0.96 | 1.50 ± 0.75 | <0.001 |
| FLI | 98.23 ± 3.04 | 93.45 ± 9.61 | <0.001 | 97.98 ± 3.18 | 92.64 ± 10.75 | <0.001 |
| Presence of Metabolic Syndrome (n, %) | 75, 61.0% | 13, 16.9% | <0.001 | 75, 52.8% | 13, 22.4% | <0.001 |
1 GH peak response after GHRH + ARG was classified as blunted when GH peak was ≤4.2 mg/L, and 2 sufficient when GH peak was ≥4.2 mg/L. 3 IGF-1 levels were classified as deficient (IGF-1 deficiency) when the SDS from the mean was <−2 for age and gender, and 4 sufficient when the SDS ranged from >−2 to 2.24.