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. 2019 Sep 15;8(9):1089. doi: 10.3390/cells8091089

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fisetin significantly suppresses the IL-22-induced activation of PI3K/Akt/mTOR signaling in NHEK. Western blot determined protein expression levels of (A,B) PI3-K (p110 and p85), and (C,D) phosphorylation of Akt (at Ser473 and Thr308), and (E) phosphorylation of mTOR (at Ser2448 and Ser2481), and (F) phosphorylation of p-p70S6K (Thr389), as compared with untreated cells (control) and IL-22-treated cells only. (B,D,G) graphs of the relative intensity of normalized protein components, where each bar depict means +/-SD of three different experiments. **, *** and **** indicate p < 0.01, p < 0.001, and p < 0.0001 vs. control for IL-22-treated only or vs. IL-22 for fisetin-treated cells.