Table 2.
Multivariable Models of Association of ICH Lesion Location with Day 30 Outcomes: All Locations (top) and Thalamus vs. Non-Thalamus (bottom)
| Odds Ratio (95% CI) | ||||||
|---|---|---|---|---|---|---|
| Mortality (n=428) | mRS 4–6 (n=434) | NIHSS >4 (n=376) | SIS <60 (n=310) | BI <86 (n=388) | EQ-VAS <50 (n=298) | |
| Thalamus | 4.80 (1.44–15.94)** | 7.05 (2.49–19.95)*** | 3.81 (1.54–9.43)*** | 2.19 (0.73–6.64) | 9.55 (2.66–34.32)*** | 2.06 (0.93–4.57)* |
| IT (ICH*Thalamus) | 1.42 (1.21–1.67)*** | 1.49 (1.20–1.85)*** | ||||
| ICH Volume: Thalamus (per mL) | 1.36 (1.2–1.55)*** | 1.43 (1.21–1.70)*** | ||||
| ICH Volume: Non-Thalamus | 0.96 (0.86–1.07) | 0.96 (0.85–1.09) | ||||
| Caudate | 0.82 (0.37–1.78) | 0.68 (0.27–1.74) | 1.25 (0.64–2.45) | 0.79 (0.33–1.88) | 0.62 (0.23–1.65) | 1.04 (0.54–2.00) |
| PLIC | 0.83 (0.33–2.09) | 1.86 (0.78–4.43) | 1.08 (0.54–2.14) | 2.22 (1.06–4.68)** | 0.85 (0.36–2.04) | 0.82 (0.42–1.61) |
| ALIC | 0.08 (0.01–0.40)*** | 0.52 (0.19–1.41) | 0.53 (0.24–1.17) | 0.81 (0.32–2.09) | 0.63 (0.22–1.83) | 0.52 (0.25–1.08)* |
| GP/Putamen | 3.35 (1.30–9.68)** | 8.99 (1.57–51.35)** | 3.23 (1.33–7.87)*** | 1.82 (0.55–6.02) | 9.21 (1.18–72.07)** | 1.16 (0.54–2.51) |
| IT (ICH*GP/P) | 1.55 (1.14–2.11)*** | 1.57 (1.11–2.22)*** | ||||
| ICH Volume: GP/P (per mL) | 1.48 (1.1–2.01)** | 1.51 (1.1–2.07)** | ||||
| ICH Volume: Non-GP/P | 0.96 (0.86–1.07) | 0.96 (0.85–1.09) | ||||
| Lobar | 0.75 (0.04–14.7) | 2.5 (0.23–27.5) | 0.30 (0.09–1.00)* | 0.51 (0.11–2.35) | 4.82 (0.75–30.87)* | 0.96 (0.26–3.58) |
| Thalamus vs. Non-Thalamus | 4.81 (1.68–13.78)*** | 5.11 (1.91–13.63)*** | 4.84 (2.16–10.87)*** | 2.69 (1.001–7.2)** | 5.64 (1.62–19.62)*** | 2.14 (1.02–4.48)** |
| IT (ICH*Thalamus) | 1.34 (1.13–1.60)*** | 1.18 (1.03–1.35)** | 1.35 (1.07–1.71)** | |||
| ICH Volume: Thalamus (per mL) | 1.43 (1.28–1.61)*** | 1.32 (1.22–1.42)*** | 1.46 (1.26–1.69)*** | |||
| ICH Volume: Non-Thalamus | 1.07 (0.94–1.22) | 1.12 (0.99–1.26) | 1.08 (0.90–1.30) | |||
All models adjusted for age, ICH volume, IVH volume, admission GCS, and treatment group. BI indicates Barthel Index; EQ-VAS, EuroQol Visual Analogue Scale; GP/P, globus pallidus/putamen; IT, interaction term (ICH*Thalamus: ICH volume * thalamus location; ICH*GP/P: ICH volume * globus pallidus/putamen location); mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; and SIS, Stroke Impact Scale.
*
0.05 ≤P <0.10.
**
0.01 ≤P <0.05.
***
P<0.01.