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. 2019 Aug 21;9(22):6468–6484. doi: 10.7150/thno.35383

Figure 3.

Figure 3

The roles of BCAP31 in promoting breast cancer development. (A) Confirmation of BCAP31 knockdown (KD, shBCAP31) and re-expression (shRES) in TNBC cell lines. (B-E) The effects of BCAP31 knockdown or re-expression on the in vitro proliferation (B), (C and D) migration, invasion and (E) colony formation of HCC cells. Error bars indicate the means ± SEM. (F) In vivo tumour growth in MDA-MB231 shBCAP31 mice was significantly inhibited compared with control mice. Representative images of tumour-bearing mice are shown. (G) The dynamic change in tumour volume in subcutaneous models is shown. Error bars indicate the means ± SEM. Knockdown of BCAP31 significantly decreased tumour growth (H) and spontaneous liver metastasis (I) in MDA-MB-231 xenograft nude mice models. Representative images of H&E-stained liver tissues from the xenograft groups. Arrowheads indicate metastatic nodules in the liver.