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. 2019 Jun 26;14(11):1125–1140. doi: 10.1080/15592294.2019.1633867

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — EZH2 regulates the PI3K pathway through IGF1R in the HG3 CLL cell line. (a) Snap shot of 100 kb region showing peak enrichment for EZH2 and HK27me3 on the EZH2 binding region on the IGF1R gene for M-CLL and U-CLL samples. (b) Box plots for EZH2 and H3K27me3 enrichment over the IGF1R gene between M-CLL and U-CLL samples based on ChIP-seq data. (c) ChIP assay data showing fold enrichment of EZH2 (right side) and H3K27me3 (left side) over IgG Ab on IGF1R promoter using 16 independent CLL samples. (d and e) Box plot showing expression levels of EZH2 and IGF1R between M-CLL and U-CLL samples. (f and g) ChIP assay data showing fold enrichment of EZH2 and different histone modifications over IGF1R gene promoter in EZH2 downregulated HG3 cells. (h) Fold change expression levels of EZH2 and IGF1R expression levels in EZH2 siRNA downregulated HG3 cells.