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. 2019 Sep 19;11(9):487. doi: 10.3390/pharmaceutics11090487

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic illustrating the division of the agar plate into zones. Zones 1-5 are numbered starting from the inner circle. Zone diameters: 1.0 cm, 3.0 cm, 4.4 cm, 5.8 cm, and 8.6 cm. Concentrations of released CAM (detection limit of 1 µg/mL) from PCL/PEO/CAM (B) and PCL/CAM fiber mats (C) into 1.5% (w/V) agar hydrogel at 37 °C in different time points (1 min, 30 min, 180 min) and into different zones (1–4). Error bars represent standard deviation, N = 3. Key: CAM, chloramphenicol; PCL, polycaprolactone; PEO, polyethylene oxide.