Table 4.

Characteristics of blank and drug-loaded micelles. Micelle size reported is from DLS analysis; (n.d. = not determined).

Blank	pH	Zeta Potential (mV)	Solubility (mg/mL)	Size (nm)	% Intensity	PdI
T	6.00 ± 0.02 a	−8.26 ± 4.03	-	13.86 ± 4.30	100.0%	0.132
TP	6.94 ± 0.01	−8.09 ± 1.87	-	19.93 ± 8.03	96.8%	0.205
P	7.22 ± 0.01	−3.32 ± 8.93	-	See Table S2
Cyclosporine	pH	Zeta Potential (mV)	Solubility (mg/mL) ¶	Size (nm)	% Intensity	PdI
T	6.82 ± 0.07	n.d.	4.84 ± 0.45	12.96 ± 4.03	100.0%	0.091
TP	6.88 ± 0.02	−0.02 ± 0.20 e	0.99 ± 0.23	20.31 ± 9.66	100.0%	0.192
P	7.04 ± 0.01	n.d.	0.57 ± 0.38	n.d.
Econazole Nitrate	pH	Zeta Potential (mV)	Solubility (mg/mL) #	Size	% Intensity	PdI
T	3.36 b ± 0.02	9.13 ± 1.48	3.69 ± 0.20	7.21 ± 2.15	100.0%	0.076
T c	5.1 d ± 0.14	n.d.	n.d.	12.02 ± 3.58	100.0%	0.094
TP	4.23 ± 0.10	4.52 ± 1.68	4.15 ± 0.17	17.85 ± 8.50	99.5%	0.19
P	4.23 ± 0.10	−0.71 ± 1.48	3.79 ± 0.56	n.d.
Dexamethasone	pH	Zeta Potential (mV)	Solubility (mg/mL) #	Size	% Intensity	PdI
T	6.54 ± 0.16	−11.39 ± 2.94	0.59 ± 0.03	13.44 ± 4.29	97.7%	0.165
TP	6.94 ± 0.02	−10.55 ± 4.69	0.53 ± 0.09	21.39 ± 11.54	99.6%	0.222
P	7.10 ± 0.03	−10.99 ± 3.30	1.11 ± 0.10	n.d.

^¶ measured at 36 days; ^# measured at 30 days; ^a blank T micelles brought to pH 3.3 have a comparable size (11.7 ± 2.4 nm); ^b at this pH, the logD is 2.4 and the % of unionized form is about 0.08% [30]; ^c addition of NaOH 0.5 M; ^d at this pH, the logD is 4.4 and the % of unionized form is about 8% [30]; ^e from a previous work [7], sample dilution 1:20.