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Illustration of the coagulation cascade upon vascular endothelium injury. Aptamers have been isolated to inhibit clotting factors in both the extrinsic and intrinsic pathways of the coagulation cascade. Different inhibition stages ultimately lead to the inhibition of insoluble fibrin (Factor Ia) formation. The blue cloud shapes represent aptamers that have been identified to inhibit specific clotting factors. Each Roman numeral represents the corresponding clotting factor.
