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. 2019 Jul 26;7(3):55. doi: 10.3390/biomedicines7030055

Figure 3.

Figure 3

Illustration of the clotting cascade upon vascular endothelium injury. VWF: Von Willebrand factor; ADP: adenosine diphosphate. VWF and collagen activate platelets. Upregulated GPIIb/IIIa receptors on activated platelets increase the release of thromboxane A2 and ADP, and additional platelets are activated to promote clot formation at the site of injury. The blue cloud shape represents aptamers that have been identified to inhibit the Von Willebrand factor and stops platelet activation.