Fig. 3.

The effects of the trace amine-associated receptor 1 (TAAR1) partial agonist RO5263397 on EEG spectra recorded during the initial 6-h of the dark phase in Cynomolgus macaques. a Absolute (Log) power spectrum from 0.3–100 Hz for WAKE, NREM and REM sleep during the initial 6 h of the dark phase following vehicle (0.3% Tween 80 in sterile water) or RO5263397 (0.1, 1, 10 mg/kg, p.o.) treatment. b Normalized power spectrum from 0.3–100 Hz and c corresponding delta, theta, alpha, sigma, beta, low gamma, and high gamma (left to right) frequency bands for WAKE, NREM and REM sleep following RO5263397 treatment during same 6 h of the dark phase. RO5263397 at 10 mg/kg increased activity in the delta and theta bandwidths across all vigilance states (WAKE, NREM, and REM); delta activity during NREM sleep increased after all three doses. Data are mean ± SEM (n = 5). *p ≤ 0.05 (RO5263397 as compared to the vehicle condition). A 7-day washout period elapsed between treatments