Table 1.
Sleep/wake characteristics of Cynomolgus macaques during the first 6 h of the dark phase after administration of vehicle or RO5263397 (0.1, 1, and 10 mg/kg, p.o.) 30 min before light offset in Experiment 1 (n = 6)
| Sleep-wake parameters | Vehicle (Mean ± SEM) | RO5263397 (0.1 mg/kg) | RO5263397 (1 mg/kg) | RO5263397 (10 mg/kg) |
|---|---|---|---|---|
| Time in darkness (min) | 360 | 360 | 360 | 360 |
| Total sleep time (TST; min) | 254.2 ± 14.1 | 251.8 ± 20.0 | 263.1 ± 22.4 | 164.3 ± 14.7a |
| Sleep efficiency (%) | 70.6 ± 3.9 | 69.9 ± 5.6 | 73.1 ± 6.2 | 45.6 ± 4.1a |
| Sleep onset latency (SOL; min) | 22.0 ± 3.1 | 19.4 ± 4.1 | 17.8 ± 4.5 | 24.0 ± 4.4 |
| REM onset latency (ROL; min) | 93.5 ± 12.7 | 80.7 ± 19.3 | 87.3 ± 21.1 | 159.9 ± 32.2 |
| Wake after sleep onset (WASO; min) | 83.8 ± 11.1 | 88.8 ± 18.1 | 79.1 ± 20.7 | 171.7 ± 13.4a |
| REM sleep duration (min) | 35.0 ± 8.6 | 38.8 ± 4.6 | 30.5 ± 7.0 | 4.8 ± 2.7a |
| Stage N1 NREM duration (min) | 4.6 ± 1.3 | 6.2 ± 1.6 | 3.6 ± 1.2 | 2.0 ± 1.3 |
| Stage N2 NREM duration (min) | 152.1 ± 13.5 | 138.1 ± 12.6 | 156.0 ± 18.7 | 116.7 ± 16.0 |
| Stage N3 NREM duration (min) | 62.5 ± 17.0 | 68.7 ± 16.1 | 73.0 ± 22.6 | 40.8 ± 4.4a |
| Cumulative NREM sleep duration (min) | 219.2 ± 14.0 | 212.9 ± 19.9 | 232.6 ± 21.0 | 159.5 ± 12.4a |
| REM / NREM ratio | 0.166 ± 0.047 | 0.194 ± 0.036 | 0.136 ± 0.032 | 0.026 ± 0.014a |
| Awakenings (#) | 45.5 ± 5.9 | 50.2 ± 5.2 | 49.5 ± 9.4 | 58.5 ± 6.8 |
| NREM / REM Cycles (#) | 6.3 ± 1.1 | 6.8 ± 1.2 | 6.2 ± 1.1 | 1.3 ± 0.6a |
ap ≤ 0.05 vs. vehicle