Abstract
Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.
Keywords: GLP-1R, Liraglutide, PKA/CREB pathway, Inflammation, Osteoarthritis
Main text
Qihong Que. and colleagues [1] found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.
We declare no competing interests.
Conclusions
Qihong Que. and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research.
Acknowledgements
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Abbreviations
- CREB
cyclic adenosine monophosphate (cAMP) response element-binding
- OA
osteoarthritis
- PKA
protein kinase A
Authors’ contributions
LW was a major contributor in writing the manuscript. All authors read and approved the final manuscript.
Funding
No funding was obtained for this study.
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Competing interests
The authors declare that they have no competing interests.
Footnotes
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Reference
- 1.Que Q, Guo X, Zhan L, et al. The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis. J Inflamm (Lond) 2019;16:13. doi: 10.1186/s12950-019-0218-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
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Data Availability Statement
Not applicable.