Figure 4.

Unfractionated and Membrane-Associated Co-Expression Networks Demonstrate Minimal Overlap. A hypergeometric one-tailed Fisher’s exact test (FET) was used to identify modules that shared significant overlap of protein members between the membrane-fractionated (M) network and that of unfractionated control, AsymAD, and AD cases derived from the Baltimore Longitudinal Study of Aging (BLSA). The 16 modules of the unfractionated (U) BLSA network, clustered by eigenprotein relatedness, are shown on the x-axis along with their top protein ontologies. These BLSA modules were aligned to the 27 modules of the membrane-associated network (y-axis). Module gene symbol lists showed either significant overlap (red) or no significant under- or over-representation (white) in protein membership. Numbers are positive signed −Log₁₀(FDR-corrected p values) representing the degree of overlap (* p < 0.05; ** p < 0.01). Notable overlapping modules are highlighted to the right of the FET results.