Figure 5.
TUBO re-challenge in mice rejected tumors after bispecific antibody therapy. (a, b) Balb/c mice that rejected TUBO tumors after BsPD-L1xrErbB2, anti-ErbB2 alone, anti-PD-L1 alone or the combination therapy from different experiments were collected and 2 × 106 TUBO tumor cells were injected in the opposite flank of mice in each group and tumor growth was monitored. TUBO tumors did not grow in any of the group of mice that had rejected tumors before. (c) Data is shown for the percentage of mice rejecting tumors/group (gray bars, tumor-bearing mice; black bars, tumor-free mice for at least 60 d). Number represents the tumor-free mice/total number of mice in a group.