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. 2019 Sep 5;8(11):e1659092. doi: 10.1080/2162402X.2019.1659092

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Figure 1. — PDK1 influences PD-L1 expression in ovarian cancer. (a–c) Knockdown efficiency of PDK1 assessed via qPCR and immunoblotting in A2780CP and SKOV-3 cells (a). PD-L1 expression in A2780CP and SKOV-3 cells after knockdown of PDK1 evaluated via immunoblotting (a), qPCR (b) and flow cytometry (c). (d–f) Overexpression of PDK1 in OVCAR3 cells assessed via qPCR and immunoblotting (d). PD-L1 expression in OVCAR3 cells overexpressing PDK1 detected via immunoblotting (d), qPCR (e) and flow cytometry (f). (g) Representative immunohistochemistry samples showing similar expression patterns of PDK1 and PD-L1 within ovarian cancer. (h) Statistical analysis showing a positive correlation between PDK1 and PD-L1 in an ovarian cancer tissue array. Representative data from three experiments are shown (*P < .05, **P < .01, ***P < .001, ****P < .0001).