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. 2019 Sep 5;8(11):e1659092. doi: 10.1080/2162402X.2019.1659092

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Figure 3. — PDK1 expressed in ascites-derived ovarian cancer cells impairs CD8⁺ T cell function. (a) PD-L1 mRNA expression in paired primary ovarian cancer and ascites-derived ovarian cancer cells. (b) Representative results of flow cytometry showing PD-L1 surface expression in primary ovarian cancer and ascites-derived cancer cells. c-e Transient knockdown of PDK1 mRNA and protein expression (c) in representative cases of ascites-derived ovarian cancer cells. PD-L1 protein (c), mRNA (d) and surface expression (e) in representative cases of ascites-derived ovarian cancer cells with knockdown of PDK1. (f) Representative results showing IFN-γ secreted by CD8⁺ T cells co-cultured with ascites-derived ovarian cancer cells depleted of PDK1 or control cells. g Statistical analysis of Figure 3f (n = 8) (*P < .05, ***P < .001, **** P < .0001).